Stable Inhibition of Nuclear Factor kB in Cancer Cells Does Not Increase Sensitivity to Cytotoxic Drugs
نویسندگان
چکیده
Several reports indicated that nuclear factor kB (NF-kB) activation by cytokines, cytotoxic drugs, or ionizing radiation protects cells against apoptosis. Therefore, we investigated the consequence of NF-kB inhibition on the efficiency of antineoplastic agents. HPB, HCT116, MCF7, and OVCAR-3 cells stably expressing a dominant negative IkBa inhibitor showed a decreased NF-kB activation following treatment with tumor necrosis factor a and various chemotherapeutic agents. However, there was no difference in survival between parental cells and cells expressing mutated IkBa. These studies suggest that, at least in these cell lines, stable NF-kB inhibition did not modify the response to cytotoxic drugs.
منابع مشابه
Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugs.
Several reports indicated that nuclear factor kappaB (NF-kappaB) activation by cytokines, cytotoxic drugs, or ionizing radiation protects cells against apoptosis. Therefore, we investigated the consequence of NF-kappaB inhibition on the efficiency of antineoplastic agents. HPB, HCT116, MCF7, and OVCAR-3 cells stably expressing a dominant negative IkappaBalpha inhibitor showed a decreased NF-kap...
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